Enclomiphene vs. Clomid for Men: What's the Difference?

One is a component of the other

Clomiphene citrate is a mixture of two isomers: enclomiphene and zuclomiphene. They behave differently in the body and clear from it at different rates. Enclomiphene is the isomer most associated with the effect on hormonal signalling that raises the body's own testosterone production.

Using enclomiphene on its own is an attempt to isolate that effect rather than deliver both isomers together.

What both approaches have in common

Both work upstream, on the signals between the brain and the testes, rather than supplying testosterone directly. That is why they come up in conversations about preserving the body's own production, and in conversations about fertility.

How a provider decides

• —Baseline laboratory results, particularly LH, FSH, and testosterone
• —Whether the underlying cause of low testosterone is likely to respond to this approach
• —Fertility plans
• —Medical history, contraindications, and other medications
• —Tolerability and response over time, assessed at follow-up

Where Elevate-T fits

Vitality's Elevate-T pathway is a compounded oral treatment containing enclomiphene, DHEA, pregnenolone, and zinc. It is one of two clinician-selected pathways within the Men's Hormone Optimization program and is considered for appropriate patients after provider review.

Enrolling in a program is not a guarantee of any prescription. Treatment is prescribed only when a Vitality provider determines it is medically appropriate.